Theoretical and NMR Conformational Studies of β-Proline Oligopeptides With Alternating Chirality of Pyrrolidine Units
نویسندگان
چکیده
1 Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia, Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russia, 3 Institute of Organic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany, 4 Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany, 5 Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia
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β-Phenylproline: the high β-turn forming propensity of proline combined with an aromatic side chain.
The conformational propensities of the proline analogue bearing a phenyl substituent attached to the β carbon, in either a cis or a trans configuration relative to the carbonyl group, have been investigated. The behaviour of cis- and trans(βPh)Pro has been compared with that of proline in homochiral and heterochiral dipeptide sequences. NMR and IR studies as well as X-ray diffraction analysis p...
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